1. Introduction. Plane warts are smooth, flat, or slightly elevated and are usually skin coloured or greyish yellow but may be pigmented. They are round or polygonal in shape and vary in size from 1 to 5 mm or more in diameter. (HealthDay)—Oral isotretinoin shows a better and earlier response than topical isotretinoin for the treatment of plane warts, according to a small study published online Sept. 13 in the. At that time I was taking isotretinoin for acne. When I was 17 I took gardasil shot. I never had warts in my mouth but I'm very afraid with the possibility of developing oral cancer from these exposures. Oral isotretinoin is effective in the treatment of recalcitrant facial plane warts. International Scholarly Research Notices is a peer-reviewed, Open Access journal covering a wide range of subjects in science, technology, and medicine. Isotretinoin therapy has furthermore proven effective against genital warts in experimental use, but is rarely used for this indication as there are more effective treatments. Isotretinoin may represent an efficacious and safe alternative systemic form of therapy for recalcitrant condylomata acuminata (RCA) of the cervix. Hello, Research had showed that some patients had benefitted after isotretinoin for genital warts but it is not the commonly followed treatment. HealthDay News — Oral isotretinoin shows a better and earlier response than topical isotretinoin for the treatment of plane warts, according to a small study published online in the International Journal of Dermatology. In the accompanying Perspective article, Bouwes Bavinck and Feltkamp 2 imply that the complex may represent a breakthrough treatment for warts, and citing a review by Gibbs et al., 3 they state. Genital warts in immunocompromised patients can be extensive and recalcitrant to treatment. We report a case of recalcitrant genital warts in a female patient with systemic lupus erythematosus (SLE), who achieved complete remission with a combination approach of surgical debulking and oral isotretinoin at an initial dose of 20 mg/day with a gradual taper of dose over 8 months. She had. I did get warts on my hand while I was on Accutane. I had a big one on my left palm but I got a lot of smaller ones later, one of them right under my index finger nail (very painful).